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Pathology-
It is the science of the nature and the causes of disease which
involves changes in structure and functions.
Bacteriology- it is the science of micro organisms.
Infection and infectious diseases-
The majority of human diseases are caused by biological agents
i.e. living organisms, ranging in size from the smallest, filter
passing, ultramicroscopic, parasitic, viruses, to large worms
several feet in length of these. The microorganisms visible only
under microscope are greater importance. The greatest of the
recent advances in medicine have been the developments in
chemotherapy in the last 40 years, with the resultant control
over some but not all of the diseases. But as some diseases are
controlled, others become more important and so on it goes.
All microorganisms do not produce disease. In fact, the body
normally harbours several types of organisms which are
considered ‘normal flora’. The majority are non-pathogenic i.e.
cannot produce disease. Some are pathogenic but not at the
numbers present, some organisms are even beneficial to us.
Some common terms used in Pathology
Tissue-
is a collection of cells having similar structure and function
e.g. Muscle tissue, Nerve tissue
Organ-
is a
collection of various tissues having same origin and same
function. e.g. Liver, Lungs, Heart
System-
is composed of various types of tissues subserving a definite
function in the body. e.g. Respiratory system, Digestive system
Inflammation-
means a characteristic local reaction of the living tissue in
response to an injury or an infection. All inflammation will
have the following features
a) Redness
(Rubor)
b) Raised
temperature (Calor)
c) Swelling
(Tumor)
d) Pain at
the site of inflammation (Dolor)
Histology-
study of the structure of various tissues in health & disease is
called histology.
Pathogenesis-
study of the mechanism of development of a disease is called
pathogenesis.
Pathogens- disease producing micro-organisms are called
pathogens.
Commensals
(non-pathogens) - all micro-organisms present within the body
and in the environment are not harmful to human beings. The
organisms which are normally present within the human body and
are not harmful are called Commensals of non-pathogens. Many a
time they subserve a beneficial purpose to human beings.
Degeneration- means withering away of cells or tissue.
Regeneration
– means regrowth of cells of tissue.
Hyperplasia- means excessive proliferation (i.e. growth
with the increase in the number of cells)
Hypoplasia-
means sub-normal or less than normal rate of proliferation of
cells
Aplasia-
means total absence of proliferation of cells
Hypertrophy-
means swollen u[ condition (i.e. increase in size) of
cells/tissue/organ
Atrophy-
means shrunken up condition (i.e. decrease in size) of
cells/tissue/organ
Necrosis-
means death of cells/tissue/organ
Gangrene-
means massive necrosis (i.e. death of tissue over a wide area)
due to lack of blood supply to the part concerned.
Classification of Micro organisms:
1.
Bacteria- very minute living organisms belonging to
the plant kingdom. They are
unicellular and contain no chlorophyll. They measure only a
few microns in size.
Bacteria are classified into three different manners.
According to:
a) Shape
Spherical shaped - Cocci
Rod shaped - Bacilli
Spiral shaped - Spirochetes
b) Grouping arrangement
Grapelike cluster - Staphylococci
Chainlike - Streptococci
c) Staining method
Red color - Gram-ve Meningococci, Gonococci
Blue color - Gram+ve Staphylococci,
Streptococci
2.
Viruses- Ultramicroscopic organisms (smaller than
bacteria). Unlike bacteria
cannot be cultivated on artificial media. There are two types
of viruses, small and
large.
Examples- Small- Chicken pox, small pox, measles, herpes,
mumps
Large- Atypical pneumonia lymphogranuloma
venereum
3.
Rickettsiae- Micro-organisms larger than viruses
smaller than bacteria responsible
for causing diseases like typhus, rocky mountain spotted
fever (rare in India)
4.
Protozoa- Minute unicellular
organisms belonging to the animal kingdom e.g.
E.Histolytica, G.Lamblia,
5. Fungi- Minute unicellular
organism belonging from plant life (larger than bacteria)
e.g. Candida, Actinomycetes

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