All of the following diseases includes in study of medicine.
1. Cardiovascular diseases-
Major manifestation of cardiovascular diseases-Chest pain, Breathlessness (dyspnoea), Acute circulatory failure (cardiogenic shock), Heart failure, hypertension, Abnormal heart sounds & murmurs, presyncope, & syncope, cardiac arrest & sudden cardiac death.
Disorders of heart rate, rhythm & conduction- like sinus rhythms, atrioventricular & bundle branch block, sinoatrial diseases (sick sinus syndrome)
Coronary heart disease- stable angina, unstable angina, myocardial infarction, cardiac risk of non-cardiac surgery
Vascular disease- Peripheral arterial disease, diseases of the avorta.
Diseases of heart valves-Rheumatic heart diseases, mitral valve diseases.
Congenital heart diseases-persistent ductus   arteriosus,
Diseases of the myocardium-Acute myocarditis,   cardiomyopathy, cardiac tumours
Diseases of the pericardium

2. Respiratory diseases-
Major manifestation of lung disease-Cough, dyspnoea, chest pain, haemoptysis, sleep disordered breathing. Respiratory failure.
Obstructive pulmonary diseases- Asthma, bronchiectasis, cystic fibrosis
Infections of the respiratory system-
pneumonia, tuberculosis, Upper respiratory tract infection.
Tumours of the bronchus & lung
Diseases of chest wall

3. Kidney & genitourinary diseases-
Major manifestation of renal & urinary tract diseases-
General manifestation of renal disease-   
Disorders of urine volume, haematuria, proteinuria, oedema, obstruction of the urinary tract, renal failure, Renal replacement therapy.
Congenital abnormalities of the kidneys & urinary system.
Infection of the kidney & urinary tract       
Urinary tract calculi & nephrocalcinosis  Tumours of the kidney & genitourinary tract.

4. Dibetes mellitus
Major manifestation of disease-Hyperglycaemia, diabetic ketoacidosis, Complications of diabetes, hypoglycaemia 
Management of diabetes- Dietary management, oral hypoglycaemic drugs, insulin, self-assessment of glycaemic control.
Acute metabolic complications

5. Endocrine diseases-
Major manifestation of thyroid diseases-  Hyperthyroidism, hypothyroidism, simple goiter,  malignant tumours.
Major manifestation of reproductive disease-male hypogonadism, gynaecomastia, erectile impotence, short stature & delayed puberty. infertility 
Major manifestation of diseases of  parathyroid glands- hypercalcaemia, hypocalcaemia
Major manifestation of adrenal diseases
Major manifestation of diseases of the endocrine pancreas- spontaneous hypoglycaemia
Major manifestation of hypothalamic & pituitary diseases- hyperpituitarism, galactorrhoea
 
6. Alimentary tract & pancreatic disorders
Major manifestation of gastrointestinal tract- Dysphasia, dyspepsia vomiting, Diarrhoea Gastrointestinal bleeding, malabsorption, weight loss constipation, abdominal pain.
Diseases of the mouth & salivary glands
Diseases of the oesophagus
Diseases of the stomach &duodenum
Diseases of the small intestine
Diseases of the pancreas
Inflammatory bowel Disease
Irritable bowel syndrome

7.Blood disorders.
Major manifestation of Blood disease-Anemia, High haemoglobin, Leucopenia (low white count) Leucosytosis (high white count), splenomegaly,‘bleeding,thrombocytopenia(lowplatelets),
Thrombocytosis (high platelets), venous thrombosis Abnormal coagulation screen,

8.Musculoskeletal disorders.
Major manifestation of musculoskeletal diseases-Joint pain, Regional periarticular pain back & neck pain, bone pain, muscle pain & weakness, systemic illness.
Osteoarthritis
Inflammatory joint disease -Rheumatoid arthritis joint infections Fibromyalgia
Diseases of bone-Osteoporosis, osteomalocia & rickets,
Systemic connective tissue disease.

9. Skin disease
Major manifestation of skin diseases-The changing mole, itch (pruritus), The scaly rash, Erythroderma, photosensitivity Blisters, too little or too much hair, valval itch.
Eczema
Some common skin infections & infestations
Pressure sores
Disorders of pigmentation
Disorders of the nails
Skin tumours Dermatological surgery. 

10. Nervous system-
Clinical examination of the nervous system.
Major manifestation of the nervous system disease.
Headache & facial pain, Dizziness, black outs & ‘funny turns’, sleep disorder, Disorders of movement, sensory disturbance, coma & brain death, disturbance of cortical function speech, swallowing & brain-stem disturbance, visual disturbance, sphincter disturbance, Cerebrovascular diseases
Inflammatory diseases
Degenerative diseases- Parkinson’s disease, & a kinetic-rigid –syndrome Wilson’s disease, Motor neuron disease
Disease of nerve & muscle.
Infections  of the nervous system